Different cell fates after mitotic slippage: From aneuploidy to polyploidy. (3rd March 2016)

• Record Type: Journal Article
• Authors: Ohashi, Akihiro
• Is Part Of: Molecular & cellular oncology. Volume 3:Number 2(2016)
• Publication Date: 2016-03-03
• Subjects: Aneuploidy -- DNA damage response -- mechanisms of oncogenesis and tumor progression -- mitotic inhibitor -- mitotic slippage -- mode of action of anticancer agents -- novel therapeutic agents -- novel therapeutic targets -- oncogenes and tumor suppressor genes -- polyploidy -- proteotoxic stress -- p53 -- spindle assembly checkpoint -- unfolded protein response; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2015.1088503
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: The molecular mechanism responsible for cell fate after mitotic slippage remains unclear. We investigated the different postmitotic effects of aneuploidy versus polyploidy using chemical inhibitors of centromere-associated protein-E (CENP-E) and kinesin family member 11 (KIF11, also known as Eg5). Aneuploidy caused substantial proteotoxic stress and DNA damage accompanied by p53-mediated postmitotic apoptosis, whereas polyploidy did not induce these antiproliferative effects.