Role of the lysophosphatidylinositol/GPR55 axis in cancer. (January 2016)

• Record Type: Journal Article
• Authors: Falasca, Marco; Ferro, Riccardo
• Is Part Of: Advances in biological regulation. Volume 60(2016)
• Page Start: 88
• Page End: 93
• Publication Date: 2016-01
• Subjects: LPI -- G protein-coupled receptor 55 -- Cancer -- ABC transporters -- Cannabidiol; Cellular control mechanisms -- Periodicals; Biological control systems -- Periodicals; Molecular biology -- Periodicals; Periodicals; 571.74
• DOI: 10.1016/j.jbior.2015.10.003
• Languages: English
• ISSNs: 2212-4926

Abstract

Abstract: Lysophosphatidylinositol (LPI) is a well-known bioactive lipid that is able to activate signalling cascades relevant to cell proliferation, migration, survival and tumourigenesis. It is well-established that the G protein-coupled receptor 55 (GPR55) is the specific receptor for LPI. Several investigations have demonstrated that the signalling pathways activated by LPI through its receptor GPR55 play a pivotal role in different cancer type. This review focuses on the role of the LPI/GPR55 axis, in particular with regards to its pharmacological potential therapeutic exploitation.