Sleep homeostasis, habits and habituation. (June 2017)

• Record Type: Journal Article
• Authors: Vyazovskiy, Vladyslav V; Walton, Mark E; Peirson, Stuart N; Bannerman, David M
• Is Part Of: Current opinion in neurobiology. Volume 44(2017)
• Page Start: 202
• Page End: 211
• Publication Date: 2017-06
• Subjects: Neurobiology -- Periodicals; 573.8
• DOI: 10.1016/j.conb.2017.05.002
• Languages: English
• ISSNs: 0959-4388

Abstract

Highlights: Synaptic GluA1 subunit levels increase during waking and decrease during sleep. GluA1-dependent plasticity is implicated in short-term habituation. Sleep may play a role in dishabituation, which restores attentional capacity. Sleep disruption favours model-free/habit-based forms of behaviour. Abstract : The importance of sleep for behavioural performance during waking is long-established, but the underlying reasons and mechanisms remain elusive. Waking and sleep are associated with changes in the levels of GluA1 AMPAR subunit in synaptic membranes, while studies using genetically-modified mice have identified an important role for GluA1-dependent synaptic plasticity in a non-associative form of memory that underlies short-term habituation to recently experienced stimuli. Here we posit that sleep may play a role in dishabituation, which restores attentional capacity and maximises the readiness of the animal for learning and goal-directed behaviour during subsequent wakefulness. Furthermore we suggest that sleep disturbance may fundamentally change the nature of behaviour, making it more model-free and habitual as a result of reduced attentional capacity.