Carbazole-containing sulfonamides and sulfamides: Discovery of cryptochrome modulators as antidiabetic agents. Issue 3 (1st February 2016) - Humphries, Paul S.
Graphical abstract: Abstract: A series of novel carbazole-containing sulfonamides and sulfamides were synthesized. A structure–activity relationship study of these compounds led to the identification of potent cryptochrome modulators. Based on the results of efficacy studies in diet-induced obese (DIO) mice, and the desired pharmacokinetic parameters, compound41 was selected for further profiling.