Novel carbocyclic nucleoside analogs suppress glomerular mesangial cells proliferation and matrix protein accumulation through ROS-dependent mechanism in the diabetic milieu. II. Acylhydrazone-functionalized pyrimidines. Issue 3 (1st February 2016)

• Record Type: Journal Article
• Authors: Bouhadir, Kamal H.; Koubeissi, Ali; Mohsen, Fatima A.; El-Harakeh, Mira Diab; Cheaib, Rouba; Younes, Joan; Azzi, Georges; Eid, Assaad A.
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 26:Issue 3(2016)
• Page Start: 1020
• Page End: 1024
• Publication Date: 2016-02-01
• Subjects: Carbocyclic nucleosides -- Acylhydrazones -- Diabetic nephropathy -- Uracil -- Thymine -- Cytosine; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.12.042
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: We report herein the synthesis of a novel series of carbocyclic acylhydrazone derivatives of uracil, thymine and cytosine from the corresponding nucleic bases and their biological activity to treat diabetic nephropathy. Intriguingly, five derivatives significantly reduced high-glucose induced glomerular mesangial cells proliferation and matrix protein accumulation in vitro. The anti-oxidative effects displayed by these molecules suggest that their activity might involve a ROS-dependent mechanism.