NaOH-promoted reaction of 1, 1-dihaloalkenes and 1H-azoles: synthesis of dihetaryl substituted alkenes. (11th October 2018)

• Record Type: Journal Article
• Authors: Zhang, Chen; Shi, Yu-Long; Zhang, Li-Yu; Yuan, Dong-Peng; Ban, Meng-Tao; Zheng, Jia-Yao; Liu, Deng-Hui; Guo, Shun-Na; Cui, Dong-Mei
• Is Part Of: New journal of chemistry. Volume 42:Number 21(2018)
• Page Start: 17732
• Page End: 17739
• Publication Date: 2018-10-11
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c8nj02756k
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : We have developed a useful and simple process for the NaOH-promoted reaction of 1, 1-dihaloalkenes and 1 H -azoles to afford dipyrazolyl alkenes under mild and transition-metal-free conditions. Abstract : An efficient NaOH-promoted synthesis of dihetaryl substituted alkenes from 1, 1-dihaloalkenes and 1 H -azoles under mild conditions has been developed. The reaction occurred in moderate to good yields and tolerated aliphatic, heterocyclic, and aryl substituted 1, 1-dihaloalkenes containing functionalities such as nitriles, ethers, and halogens. Imidazoles and triazoles also afforded the desired products.