Emerging exposures of developmental toxicants. Issue 2 (April 2017)
- Record Type:
- Journal Article
- Title:
- Emerging exposures of developmental toxicants. Issue 2 (April 2017)
- Main Title:
- Emerging exposures of developmental toxicants
- Authors:
- Wolff, Mary S.
Buckley, Jessie P.
Engel, Stephanie M.
McConnell, Rob S.
Barr, Dana B. - Abstract:
- Abstract : Purpose of review: The purpose of this review is to identify emerging developmental toxicants that are understudied in children's health. Exposures may arise from new products designed to improve utility, to reduce toxicity, or to replace undesirable chemicals. Exposures to less-toxic chemicals may also be significant if they are very commonly used, thereby generating widespread exposure. Sources of exposure include the workplace, personal, home, and office products; food, water, and air. Recent findings: We describe eight exposure categories that contain numerous potential developmental toxicants. References are discussed if reported in PubMed during the past decade at least 10 times more frequently than in 1990–2000. Examples included phthalates, phenols, sunscreens, pesticides, halogenated flame retardants, perfluoroalkyl coatings, nanoparticles, e-cigarettes, and dietary polyphenols. Replacements are often close structural homologs of their precursors. We suggest biomonitoring as preferred means of exposure assessment to emerging chemicals. Some existing analytic methods would require minimal modification to measure these exposures, but others require toxicokinetic and analytic investigation. Summary: A deliberate strategy for biomonitoring of emerging replacement chemicals is warranted, especially in view of concerns regarding developmental toxicity. To prevent adverse health effects, it is important to characterize such exposures before they become widelyAbstract : Purpose of review: The purpose of this review is to identify emerging developmental toxicants that are understudied in children's health. Exposures may arise from new products designed to improve utility, to reduce toxicity, or to replace undesirable chemicals. Exposures to less-toxic chemicals may also be significant if they are very commonly used, thereby generating widespread exposure. Sources of exposure include the workplace, personal, home, and office products; food, water, and air. Recent findings: We describe eight exposure categories that contain numerous potential developmental toxicants. References are discussed if reported in PubMed during the past decade at least 10 times more frequently than in 1990–2000. Examples included phthalates, phenols, sunscreens, pesticides, halogenated flame retardants, perfluoroalkyl coatings, nanoparticles, e-cigarettes, and dietary polyphenols. Replacements are often close structural homologs of their precursors. We suggest biomonitoring as preferred means of exposure assessment to emerging chemicals. Some existing analytic methods would require minimal modification to measure these exposures, but others require toxicokinetic and analytic investigation. Summary: A deliberate strategy for biomonitoring of emerging replacement chemicals is warranted, especially in view of concerns regarding developmental toxicity. To prevent adverse health effects, it is important to characterize such exposures before they become widely disseminated. … (more)
- Is Part Of:
- Current opinion in pediatrics. Volume 29:Issue 2(2017:Apr.)
- Journal:
- Current opinion in pediatrics
- Issue:
- Volume 29:Issue 2(2017:Apr.)
- Issue Display:
- Volume 29, Issue 2 (2017)
- Year:
- 2017
- Volume:
- 29
- Issue:
- 2
- Issue Sort Value:
- 2017-0029-0002-0000
- Page Start:
- Page End:
- Publication Date:
- 2017-04
- Subjects:
- child health -- environmental exposures -- exposure biomarkers -- orphan exposures
Pediatrics -- Periodicals
Pediatrics -- Periodicals -- Bibliography -- Periodicals
618.92 - Journal URLs:
- http://journals.lww.com/co-pediatrics/pages/default.aspx ↗
http://journals.lww.com/pages/default.aspx ↗ - DOI:
- 10.1097/MOP.0000000000000455 ↗
- Languages:
- English
- ISSNs:
- 1040-8703
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3500.776800
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 8047.xml