Screening for Depression and Anxiety in Patients with Active Uveitis. (3rd October 2018)

• Record Type: Journal Article
• Authors: Onal, Sumru; Oray, Merih; Yasa, Cagla; Akman, Mehmet; Uludag, Gunay; Koc Akbay, Aylin; Tugal-Tutkun, Ilknur
• Is Part Of: Ocular immunology and inflammation. Volume 26:Number (2018)
• Page Start: 1078
• Page End: 1093
• Publication Date: 2018-10-03
• Subjects: Anxiety -- BDI-II -- depression -- general health -- NEI-VFQ-25 -- quality of life -- SF-36 -- STAI-I -- uveitis -- vision; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2017.1319959
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose : To screen for psychological disorders in patients with active uveitis. Methods : Patients were screened for depression (BDI-II), state anxiety (STAI-I), VR-QOL (NEI-VFQ-25), and HR-QOL (SF-36). Association of depression and anxiety with sociodemographic and clinical parameters and with VR-QOL and HR-QOL were analyzed. Multivariate linear regression models were constructed for NEI-VFQ-25 and SF-36 subscales. Results : Of 99 patients, 37.3% screened positive for depression and 52.5% for anxiety. Depressed patients had lower visual acuity in the better seeing eye ( p = 0.013) and more frequently panuveitis ( p = 0.018). Anxious patients were younger ( p = 0.009), had earlier onset of uveitis ( p = 0.015), and had more frequently panuveitis ( p = 0.016). Bivariate comparisons showed significant associations between psychological disorders and VR-QOL and HR-QOL. Significant bivariate associations were mostly lost in multivariate analyses for anxiety, but were preserved for depression. Conclusions : A positive screening test for depression and anxiety is common in patients with uveitis. Low vision and panuveitis are associated with depression. Depression is associated with impairment of VR-QOL and HR-QOL.