Accuracy of the HPV status site‐specific factor 10 (SSF‐10) variable for patients with oropharyngeal cancers in the Iowa Cancer Registry, 2010‐2014. Issue 10 (22nd June 2018)

• Record Type: Journal Article
• Authors: Kahl, Amanda R.; Charlton, Mary E.; Pagedar, Nitin A.; Sperry, Steven M.; Matt, Bobbi; Platz, Charles; Lynch, Charles F.
• Is Part Of: Head & neck. Volume 40:Issue 10(2018)
• Page Start: 2199
• Page End: 2209
• Publication Date: 2018-06-22
• Subjects: American Joint Committee on Cancer (AJCC) staging -- head and neck cancer -- human papillomavirus (HPV)‐related cancer -- oropharyngeal cancer -- Surveillance, Epidemiology, and End Results (SEER); Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.25314
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: Surveillance, Epidemiology, and End Results Cancer Registries (SEER) began collecting human papillomavirus (HPV) status for upper aerodigestive tract cancers in 2010. However, classification of p16‐testing was not included in the Collaborative Stage coding guidelines, potentially leading to inconsistent coding. Methods: The HPV values for Iowa patients with oropharyngeal cancers (n = 824) were recoded based on modified guidelines that included p16 test results, and compared with the original guidelines. Results: Forty percent of patients were recoded to a different value, and the HPV testing rate increased from 45% to 55%; 56% received p16‐testing only. Of those originally coded as HPV‐type 16 (n = 187), 89% were recoded to HPV‐not otherwise specified (NOS). When comparing high‐level positive/negative/not done categories, original coding captured 81% of patients with HPV‐positive cancers. Conclusion: p16 was the most common HPV test but was inconsistently coded as HPV‐testing. p16‐positivity was also erroneously equated with HPV‐type 16. Adding a separate p16 variable would improve consistency and accuracy of HPV coding.