Improving Neurorepair in Stroke Brain Through Endogenous Neurogenesis-Enhancing Drugs. Issue 9 (September 2017)

• Record Type: Journal Article
• Authors: Wu, Kuo-Jen; Yu, Seongjin; Lee, Jea-Young; Hoffer, Barry; Wang, Yun
• Is Part Of: Cell transplantation. Volume 26:Issue 9(2017)
• Page Start: 1596
• Page End: 1600
• Publication Date: 2017-09
• Subjects: cerebral ischemia -- drug treatment -- neurogenesis -- stem cells -- subventricular zone -- brain repair; Cell transplantation -- Periodicals; Cell Transplantation; Cell transplantation; Electronic journals; Periodicals; Periodicals; 571.638
• DOI: 10.1177/0963689717721230
• Languages: English
• ISSNs: 0963-6897

Abstract

Stroke induces not only cell death but also neurorepair. De novo neurogenesis has been found in the subventricular zone of the adult mammalian brain days after stroke. Most of these newly generated cells die shortly after the insult. Recent studies have shown that pharmacological manipulation can improve the survival of endogenous neuroprogenitor cells and neural regeneration in stroke rats. As these drugs target the endogenous reparative processes that occur days after stroke, they may provide a prolonged window for stroke therapy. Here, we discuss endogenous neurogenesis-enhancing drugs and review the general status of stroke therapeutics in evaluating the field of pharmacotherapy for stroke.