MOFs Extend the Lifetime of Pd(II) Catalyst for Room Temperature Alkenylation of Enamine‐Like Arenes. Issue 20 (13th September 2018)

• Record Type: Journal Article
• Authors: Cirujano, Francisco G.; Leo, Pedro; Vercammen, Jannick; Smolders, Simon; Orcajo, Gisela; De Vos, Dirk E.
• Is Part Of: Advanced synthesis & catalysis. Volume 360:Issue 20(2018)
• Page Start: 3872
• Page End: 3876
• Publication Date: 2018-09-13
• Subjects: Indole -- Uracil -- Palladium -- MOFs -- Alkenylation; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201800817
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: The synthesis of pharmaceutically relevant scaffolds, such as substituted indoles or uracils, through the alkenylation of the "enamine‐like" aromatic C−H bond is performed at room temperature using catalytic amounts of Pd(OAc)2 in the presence of redox active, stable and reusable metal‐organic microporous frameworks. This is the first time that redox/acid active sites in the porous, non‐toxic and earth abundant robust MOF‐74 platform are used to avoid the fast deactivation of the cationic Pd species working under ambient conditions. Abstract :