Regiospecific Hydroamination of Unsymmetrical Electron‐Rich and Electron‐Poor Alkynes with Anilines Catalyzed by Gold(I) Immobilized in MCM‐41. Issue 20 (22nd August 2018)

• Record Type: Journal Article
• Authors: Liu, Dayi; Nie, Quan; Zhang, Rongli; Cai, Mingzhong
• Is Part Of: Advanced synthesis & catalysis. Volume 360:Issue 20(2018)
• Page Start: 3940
• Page End: 3948
• Publication Date: 2018-08-22
• Subjects: gold -- hydroamination -- ynamide -- propiolic acid derivative -- heterogeneous catalysis; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201800621
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: The first heterogeneous gold(I)‐catalyzed regiospecific hydroamination of ynamides and propiolic acid derivatives with anilines has been achieved by using a diphenylphosphine‐functionalized MCM‐41‐supported gold (I) complex and AgNTf2 as catalysts under mild conditions, yielding the corresponding ( E )‐ N‐ arylimines and ( Z )‐enamines in good to excellent yields with broad substrate scope. The new heterogeneous gold(I) complex can easily be prepared via a two‐step procedure from commercially available reagents and recovered by simple filtration of the reaction mixture. The recovered catalyst (Ph2 P‐MCM‐41‐AuNTf2 ) can be reused at least seven times without addition of AgNTf2 as a co‐catalyst and its catalytic efficiency remains unaltered. Abstract :