Bioinspired Deamination of α‐Amino Acid Derivatives Catalyzed by a Palladium/Nickel Complex. Issue 20 (4th September 2018)

• Record Type: Journal Article
• Authors: Deng, Gongtao; Chen, Jie; Sun, Wangbin; Bian, Kehan; Jiang, Yaojia; Loh, Teck‐Peng
• Is Part Of: Advanced synthesis & catalysis. Volume 360:Issue 20(2018)
• Page Start: 3900
• Page End: 3905
• Publication Date: 2018-09-04
• Subjects: bioinspired reactions -- C−H activation -- deamination -- synthetic methods; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201800823
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: An efficient bioinspired deamination method of both natural and unnatural amino acid derivatives has been developed. This method provides easy access to a wide variety of useful α, β ‐unsaturated carbonyl compounds. The reaction is realized with two transition metal catalysts (palladium and Nickel) in‐easy handling procedure. A possible reaction pathway is also proposed and the control experiments support the involvement of the palladium‐catalyzed inert sp 3 C−H activation as one of the key steps. Abstract :