Lack of association between LTF gene polymorphisms and different caries status in primary dentition. (20th August 2018)

• Record Type: Journal Article
• Authors: Wang, Mengchen; Qin, Man
• Is Part Of: Oral diseases. Volume 24:Number 8(2018)
• Page Start: 1545
• Page End: 1553
• Publication Date: 2018-08-20
• Subjects: caries -- genetics -- oral habits; Mouth -- Diseases -- Research -- Periodicals; 617.522
• DOI: 10.1111/odi.12939
• Languages: English
• ISSNs: 1354-523X

Abstract

Abstract: Objective: Dental caries is related to cariogenic bacteria, salivary components, oral hygiene and host susceptibility. Lactoferrin is an important antimicrobial glycoprotein in saliva; however, the role of the LTF gene in caries susceptibility is unclear. We investigated the association between LTF polymorphisms and the severity of caries. Design: Our study included 910 healthy paediatric subjects (aged 24–48 months) categorised into three groups: 403 with no caries or white‐spot lesions; 230 with moderate caries (8 ≤ dmft ≤ 12); and 277 with severe caries (13 ≤ dmft ≤ 20). Information regarding the subjects' oral habits was gathered using questionnaires. The LTF rs1126477 and rs1126478 polymorphism alleles were genotyped by Sanger sequencing. Results: The three groups showed no significant differences in LTF polymorphisms alleles, genotypes or haplotypes distribution. Multifactor dimensionality reduction analysis showed that the interactions between breastfeeding for a duration >24 months, night feeding >24 months and high frequency of sweet food intake increased the risk of caries ( p = 0.0014); however, we detected no interaction effect between the LTF polymorphisms and oral habits on caries susceptibility. Conclusions: The LTF rs1126477 and rs1126478 polymorphisms showed no association with the different levels of caries risk in our Chinese paediatric cohort.