Synthesis of α‐Iodoketones from Allylic Alcohols through Aerobic Oxidative Iodination. Issue 20 (22nd August 2018)

• Record Type: Journal Article
• Authors: Sanz‐Marco, Amparo; Možina, Štefan; Martinez‐Erro, Samuel; Iskra, Jernej; Martín‐Matute, Belén
• Is Part Of: Advanced synthesis & catalysis. Volume 360:Issue 20(2018)
• Page Start: 3884
• Page End: 3888
• Publication Date: 2018-08-22
• Subjects: isomerization -- aerobic oxidative iodination -- α-iodoketones -- α-aminoketones -- allylic alcohol; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201800661
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: An efficient method for the synthesis of α‐iodoketones from allylic alcohols and elemental iodine is reported. We show in this paper that the isomerization of allylic alcohols catalyzed by iridium(III) complexes can be combined with an aerobic oxidative iodination protocol, resulting in a straightforward method for the synthesis of a wide range of α‐iodoketones as single constitutional isomers and in high yields under mild reaction conditions. Abstract :