Comparison between open and pharmacomechanical repair of acutely thrombosed arteriovenous hemodialysis fistulae within a decade. Issue 4 (6th April 2018)

• Record Type: Journal Article
• Authors: Regus, Susanne; Almási‐Sperling, Veronika; Rother, Ulrich; Meyer, Alexander; Schmid, Axel; Uder, Michael; Lang, Werner
• Is Part Of: Hemodialysis international. Volume 22:Issue 4(2018)
• Page Start: 445
• Page End: 453
• Publication Date: 2018-04-06
• Subjects: Hemodialysis fistulae -- pharmacomechanical -- recombinant tissue‐plasminogen activator -- thrombosed AVF; Hemodialysis -- Periodicals; Renal Dialysis -- Periodicals; Renal Dialysis -- Congresses; Hemodialysis, Home -- Congresses; 617.461059
• DOI: 10.1111/hdi.12660
• Languages: English
• ISSNs: 1492-7535

Abstract

Abstract: Introduction : Different declotting techniques are available for acutely thrombosed arteriovenous hemodialysis fistulae (AVF). The aim of this single‐center study was to compare immediate and follow‐up results between surgical repair and a modified interventional lyse‐and‐wait technique characterized by prolonged local reaction times of recombinant tissue‐plasminogen activator (rtPA). Materials and Methods : We retrospectively analyzed medical records of 110 consecutively treated patients between the years 2003 and 2013. All patients were on hemodialysis (HD) and suffered from an acutely thrombosed AVF. The treatment standards changed in the course of time, wherefore we compared 2 groups: the open repair (OR) (N = 50) and the endovascular repair (ER) group (N = 60). Findings : We found no significant differences in success rates (OR 92%/ER 96.7%; P = 0.28), immediate failures (IFs) (OR 8%/ER 10%; P = 0.71), and temporary catheter placements (TCPs) (OR 10%/ER 6.7%; P = 0.52). Furthermore, there were no differences in cumulative primary patency rates (P = 0.42) and secondary patency rates (P = 0.97).The infection rate was significantly increased after OR (8%) compared to ER (0%); P = 0.026. The hospital stay in days was shorter after ER (5.2 ±2.8) vs. OR (9.0 ± 3.5); P < 0.001. Conclusion : The modified lyse‐and‐wait technique with prolonged local reaction times is a successful alternative to surgical repair for acutely thrombosed AVF. Clear benefits are less infections and significant shorter hospital stays after ER. However, OR remains the preferred treatment for aneurysms and anastomotic stenoses.