Direct C−H Trifluoromethylation of Quinoxalin‐2(1H)‐ones under Transition‐Metal‐Free Conditions. Issue 20 (30th August 2018)

• Record Type: Journal Article
• Authors: Wang, Liping; Zhang, Yuecheng; Li, Fanfan; Hao, Xinyu; Zhang, Hong‐Yu; Zhao, Jiquan
• Is Part Of: Advanced synthesis & catalysis. Volume 360:Issue 20(2018)
• Page Start: 3969
• Page End: 3977
• Publication Date: 2018-08-30
• Subjects: C−H Trifluoromethylation -- Transition-Metal-Free -- Sodium trifluoromethanesulfinate -- Quinoxalin-2(1H)-ones; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201800863
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: Disclosed herein is a direct C−H trifluoromethylation of quinoxalin‐2(1 H )‐ones with sodium trifluoromethanesulfinate. This protocol affords a series of 3‐trifluoromethylquinoxalin‐2(1 H )‐one derivatives in moderate to excellent yields under transition‐metal‐free conditions. The present methodology features utilization of the inexpensive trifluoromethyl source without transition‐metal‐catalysts, mild reaction conditions and high functional group tolerance, which promises a convenient and efficient access to pharmaceutically interesting quinoxalinones. Abstract :