Low incidence of symptomatic osteonecrosis after allogeneic HSCT in children with high‐risk or relapsed ALL – results of the ALL‐SCT 2003 trial. (20th July 2018)

• Record Type: Journal Article
• Authors: Kuhlen, Michaela; Bader, Peter; Sauer, Martin; Albert, Michael H.; Gruhn, Bernd; Güngör, Tayfun; Kropshofer, Gabriele; Lang, Peter; Lawitschka, Anita; Metzler, Markus; Pentek, Falk; Rossig, Claudia; Schlegel, Paul G.; Schrappe, Martin; Schrum, Johanna; Schulz, Ansgar; Schwinger, Wolfgang; von Stackelberg, Arend; Strahm, Brigitte; Suttorp, Meinolf; Luettichau, Irene Teichert‐von; Wößmann, Wilhelm; Borkhardt, Arndt; Meisel, Roland; Poetschger, Ulrike; Glogova, Evgenia; Peters, Christina
• Is Part Of: British journal of haematology. Volume 183:Number 1(2018)
• Page Start: 104
• Page End: 109
• Publication Date: 2018-07-20
• Subjects: osteonecrosis -- children -- haematopoietic stem cell transplantation -- ALL; Hematology -- Periodicals; Blood -- Diseases -- Periodicals; 616.15
• DOI: 10.1111/bjh.15511
• Languages: English
• ISSNs: 0007-1048

Abstract

Summary: Osteonecrosis (ON) was prospectively assessed in 557 children and adolescents in the Berlin‐Frankfurt‐Münster Stem Cell Transplantation in children with acute lymphoblastic leukaemia 2003 trial. Median age at haematopoietic stem cell transplantation (HSCT) was 10·3 years (range 0·5–26). Cumulative incidence of symptomatic ON (sON) was 9% at 5 years (standard deviation 1%), median time from HSCT to diagnosis of sON was 12·4 months (range 1–126). Multivariate analysis identified age at HSCT [10–15 years vs. <10 years: hazard ratio (HR) 3·73, P = 0·009; >15 years vs. <10 years: HR 5·46, P = 0·001], diagnosis of sON prior to HSCT and chronic graft‐versus‐host disease (yes versus no: HR 2·696, P = 0·015) as significant independent risk factors for the development of sON.