The effects of polyphenol supplementation on adipose tissue morphology and gene expression in overweight and obese humans. (3rd July 2018)

• Record Type: Journal Article
• Authors: Most, Jasper; Warnke, Ines; Boekschoten, Mark V.; Jocken, Johan W. E.; de Groot, Philip; Friedel, Angelika; Bendik, Igor; Goossens, Gijs H.; Blaak, Ellen E.
• Is Part Of: Adipocyte. Volume 7:Number 3(2018)
• Page Start: 190
• Page End: 196
• Publication Date: 2018-07-03
• Subjects: Adipose tissue -- EGCG -- Morphology -- Obesity -- Resveratrol -- Transcriptomics; Fat cells -- Periodicals; Adipocytes -- Periodicals; 611.018276
• DOI: 10.1080/21623945.2018.1469942
• Languages: English
• ISSNs: 2162-3945

Abstract

ABSTRACT: Dietary polyphenols have beneficial effects on adipose tissue mass and function in rodents, but human studies are scarce. In a randomized, placebo-controlled study, 25 (10 women) overweight and obese humans received a combination of the polyphenols epigallocatechin-gallate and resveratrol (282 mg/d, 80 mg/d, respectively, EGCG+RES, n = 11) or placebo (PLA, n = 14) supplementation for 12 weeks. Abdominal subcutaneous adipose tissue (SAT) biopsies were collected for assessment of adipocyte morphology and micro-array analysis. EGCG+RES had no effects on adipocyte size and distribution compared with PLA. However, we identified pathways contributing to adipogenesis, cell cycle and apoptosis were significantly downregulated by EGCG+RES versus PLA. Furthermore, EGCG+RES significantly decreased expression of pathways related to energy metabolism, oxidative stress, inflammation, and immune defense as compared with PLA. In conclusion, the SAT gene expression profile indicates a reduced cell turnover after 12-week EGCG+RES in overweight-obese subjects. It remains to be elucidated whether these alterations translate into long-term metabolic effects.