The role of adipocyte-specific IL-6-type cytokine signaling in FFA and leptin release. (3rd July 2018)

• Record Type: Journal Article
• Authors: Wueest, Stephan; Konrad, Daniel
• Is Part Of: Adipocyte. Volume 7:Number 3(2018)
• Page Start: 226
• Page End: 228
• Publication Date: 2018-07-03
• Subjects: gp130 -- insulin resistance -- glucose tolerance -- high fat diet -- obesity -- fat depot; Fat cells -- Periodicals; Adipocytes -- Periodicals; 611.018276
• DOI: 10.1080/21623945.2018.1493901
• Languages: English
• ISSNs: 2162-3945

Abstract

ABSTRACT: High secretion of interleukin (IL)-6 from white adipose tissue may contribute to metabolic complications in obesity. We have recently shown that IL-6-type cytokine signaling in adipocytes is involved in the development of obesity-associated hepatic insulin resistance and steatosis. In addition, we revealed that adipocyte-specific IL-6 signaling ameliorates glucose metabolism in obesity via enhancing insulin secretion. Mechanistically, IL-6 induces the release of free fatty acid (FFA) and leptin from adipocytes thereby affecting liver metabolism and pancreatic β-cell function, respectively. This commentary further discusses the role of adipocyte-specific IL-6-type cytokine signaling in the regulation of FFA and leptin release. In particular, we outline depot-specific differences in IL-6-induced basal release of the two aforementioned factors. Moreover, we provide evidence that insulin's effect on the release of FFA and leptin is adipose depot-dependent. We conclude that adipose depot-specific targeting of the IL-6 signaling pathway may be a novel approach to blunt obesity-associated metabolic complications.