Therapeutic potential of oxazole scaffold: a patent review (2006–2017). (2nd November 2018)
- Record Type:
- Journal Article
- Title:
- Therapeutic potential of oxazole scaffold: a patent review (2006–2017). (2nd November 2018)
- Main Title:
- Therapeutic potential of oxazole scaffold: a patent review (2006–2017)
- Authors:
- Kaur, Ramandeep
Palta, Kezia
Kumar, Manoj
Bhargava, Meha
Dahiya, Lalita - Abstract:
- ABSTRACT: Introduction : Oxazoles are oxygen and nitrogen containing five membered heterocyclic ring systems that are present in various anticancer, antimicrobial, antihyperglycemic, anti-inflammatory agents etc . of natural origin. These pharmacologically active oxazole derivatives have attracted numerous researchers to explore this scaffold for the design and development of newer potential therapeutic agents. A large number of synthetic oxazole containing molecules have been reported over the period that exhibited wide spectrum of pharmacological profiles. Some of them have shown promising therapeutic potential and have qualified for both preclinical and clinical evaluations. Areas covered : In this review, the patents (published during 2006–2017) focusing on the biological potential of oxazoles have been covered. Therapeutic applications and various techniques/assays employed for the in vitro/in vivo evaluation of patented derivatives have been discussed majorly. Expert opinion : Chemically oxazole offers three positions for substitution. These substituted oxazole derivatives of natural as well as synthetic origin have numerous pharmacological applications including anticancer, anti-Alzheimer's, anti-hyperglycemic, anti-inflammatory, antibacterial etc . Their pharmacological actions are mainly mediated through enzyme/receptor involved in the particular disease. The flexible nature of this ligand for various molecular level targets (enzyme/receptor) make this heterocylceABSTRACT: Introduction : Oxazoles are oxygen and nitrogen containing five membered heterocyclic ring systems that are present in various anticancer, antimicrobial, antihyperglycemic, anti-inflammatory agents etc . of natural origin. These pharmacologically active oxazole derivatives have attracted numerous researchers to explore this scaffold for the design and development of newer potential therapeutic agents. A large number of synthetic oxazole containing molecules have been reported over the period that exhibited wide spectrum of pharmacological profiles. Some of them have shown promising therapeutic potential and have qualified for both preclinical and clinical evaluations. Areas covered : In this review, the patents (published during 2006–2017) focusing on the biological potential of oxazoles have been covered. Therapeutic applications and various techniques/assays employed for the in vitro/in vivo evaluation of patented derivatives have been discussed majorly. Expert opinion : Chemically oxazole offers three positions for substitution. These substituted oxazole derivatives of natural as well as synthetic origin have numerous pharmacological applications including anticancer, anti-Alzheimer's, anti-hyperglycemic, anti-inflammatory, antibacterial etc . Their pharmacological actions are mainly mediated through enzyme/receptor involved in the particular disease. The flexible nature of this ligand for various molecular level targets (enzyme/receptor) make this heterocylce an attractive scaffold for development of effective and clinically relevant oxazole containing therapeutic agents. … (more)
- Is Part Of:
- Expert opinion on therapeutic patents. Volume 28:Number 11(2018)
- Journal:
- Expert opinion on therapeutic patents
- Issue:
- Volume 28:Number 11(2018)
- Issue Display:
- Volume 28, Issue 11 (2018)
- Year:
- 2018
- Volume:
- 28
- Issue:
- 11
- Issue Sort Value:
- 2018-0028-0011-0000
- Page Start:
- 783
- Page End:
- 812
- Publication Date:
- 2018-11-02
- Subjects:
- Anticancer -- heterocycle -- oxazole -- patent -- review
Drugs -- Patents -- Periodicals
615.10272 - Journal URLs:
- http://www.tandfonline.com/toc/ietp20/current ↗
http://informahealthcare.com/journal/etp ↗
http://informahealthcare.com ↗
http://juno.ashley-pub.com/vl=452196/cl=85/nw=1/rpsv/journal/journal7_home.htm ↗ - DOI:
- 10.1080/13543776.2018.1526280 ↗
- Languages:
- English
- ISSNs:
- 1354-3776
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3842.002960
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 8021.xml