A novel fluorescent adhesive-assisted biomimetic mineralization. Issue 40 (7th September 2018)

• Record Type: Journal Article
• Authors: Wang, Zhe; Ouyang, Yan; Wu, Zhifang; Zhang, Leiqing; Shao, Changyu; Fan, Jiayan; Zhang, Ling; Shi, Ying; Zhou, Zihuai; Pan, Haihua; Tang, Ruikang; Fu, Baiping
• Is Part Of: Nanoscale. Volume 10:Issue 40(2018)
• Page Start: 18980
• Page End: 18987
• Publication Date: 2018-09-07
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c8nr02078g
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : We propose a novel fluorescent adhesive-assisted biomimetic mineralization strategy, based on a mild self-etch adhesive containing 25 wt% polyacrylic acid-stabilized amorphous calcium phosphate nanoparticles and 1 wt% sodium fluorescein. Abstract : We propose a novel fluorescent adhesive-assisted biomimetic mineralization strategy, based on which 1 wt% of sodium fluorescein and 25 wt% of polyacrylic acid stabilized amorphous calcium phosphate (PAA-ACP) nanoparticles were incorporated into a mild self-etch adhesive (Clearfil S3 Bond) as a fluorescent mineralizing adhesive. The characterization of the PAA-ACP nanoparticles indicates that they were spherical particles clustered together, each particle with a diameter of approximately 20–50 nm, in a metastable phase with two characteristic absorption peaks (1050 cm −1 and 580 cm −1 ). Our results suggest that the fluorescent mineralizing adhesive was non-cytotoxic with minimal esthetic interference and its fluorescence intensity did not significantly decrease within 6 months. Our data reveal that the fluorescent mineralizing adhesive could induce the extra- and intra-fibrillar remineralization of the reconstituted type I collagen, the demineralized enamel and dentin substrate. Our data demonstrate that a novel fluorescent adhesive-assisted biomimetic mineralization strategy will pave the way to design and produce anti-carious materials for the prevention of dental caries.