Iridium-catalyzed direct asymmetric vinylogous allylic alkylation. Issue 84 (5th October 2018)

• Record Type: Journal Article
• Authors: Shi, Chang-Yun; Xiao, Jun-Zhao; Yin, Liang
• Is Part Of: Chemical communications. Volume 54:Issue 84(2018)
• Page Start: 11957
• Page End: 11960
• Publication Date: 2018-10-05
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc07249c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A catalytic asymmetric vinylogous allylic alkylation of α, β-unsaturated lactones with an iridium catalyst was achieved with excellent regio- and enantioselectivity. Abstract : The catalytic asymmetric vinylogous allylic alkylation of α, β-unsaturated lactones (including coumarins) was achieved with excellent regio- and enantioselectivity. Transformations of the product were carried out by means of the versatile terminal olefin and lactone moieties. The synthetic application of the present methodology was showcased by the asymmetric synthesis of an advanced synthetic Merck intermediate toward a new drug candidate.