Protein–protein interactions in trans-AT polyketide synthases. Issue 10 (3rd October 2018)

• Record Type: Journal Article
• Authors: Kosol, Simone; Jenner, Matthew; Lewandowski, Józef R.; Challis, Gregory L.
• Is Part Of: Natural product reports. Volume 35:Issue 10(2018)
• Page Start: 1097
• Page End: 1109
• Publication Date: 2018-10-03
• Subjects: Natural products -- Periodicals; Produits naturels -- Périodiques; 547.7
• DOI: 10.1039/c8np00066b
• Languages: English
• ISSNs: 0265-0568

Abstract

Abstract : An extensive and highly programmed set of inter- and intra-subunit protein–protein interactions controls chain assembly by trans -AT polyketide synthases. Abstract : Covering: up to 2018 The construction of polyketide natural products by type I modular polyketide synthases (PKSs) requires the coordinated action of several protein subunits to ensure biosynthetic fidelity. This is particularly the case for trans -AT PKSs, which in contrast to most cis -AT PKSs, contain split modules and employ several trans -acting catalytic domains. This article summarises recent advances in understanding the protein–protein interactions underpinning subunit assembly and intra-subunit communication in such systems and highlights potential avenues and approaches for future research.