Alokicenones A-H, eight tetrahydroanthracenes from the mangrove-derived Streptomyces sp. HN-A101. Issue 46 (15th November 2018)
- Record Type:
- Journal Article
- Title:
- Alokicenones A-H, eight tetrahydroanthracenes from the mangrove-derived Streptomyces sp. HN-A101. Issue 46 (15th November 2018)
- Main Title:
- Alokicenones A-H, eight tetrahydroanthracenes from the mangrove-derived Streptomyces sp. HN-A101
- Authors:
- Zhang, Dashan
Jiang, Yongjun
Li, Jiaqi
Zhang, Haojian
Ding, Wanjing
Ma, Zhongjun - Abstract:
- Abstract: Alokicenones A-H (1–8 ), eight new tetrahydroanthracenes and one known okicenone (9 ) were identified from the secondary metabolites of mangrove-derived Streptomyces sp. HN-A101. Their structures were elucidated by HRESIMS and NMR spectroscopic data. The absolute configurations of them were determined by the calculated and experimental ECD curves. Compounds1–2 and9 showed moderate cytotoxicity against HCT116 and SW620 cancer cell lines with IC50 values from 0.63 to 7.73 μ M. In addition, compounds1 –3 and7 –9 also exhibited inhibitory activities against ROCK2 or BRD4. Graphical abstract:
- Is Part Of:
- Tetrahedron. Volume 74:Issue 46(2018)
- Journal:
- Tetrahedron
- Issue:
- Volume 74:Issue 46(2018)
- Issue Display:
- Volume 74, Issue 46 (2018)
- Year:
- 2018
- Volume:
- 74
- Issue:
- 46
- Issue Sort Value:
- 2018-0074-0046-0000
- Page Start:
- 6667
- Page End:
- 6672
- Publication Date:
- 2018-11-15
- Subjects:
- Alokicenones A-H -- Mangrove-derived Streptomyces -- Cytotoxicity -- ROCK2 inhibitory activities -- BRD4 inhibitory activities
Chemistry, Organic -- Periodicals
547.005 - Journal URLs:
- http://www.elsevier.com/journals ↗
- DOI:
- 10.1016/j.tet.2018.09.049 ↗
- Languages:
- English
- ISSNs:
- 0040-4020
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8796.850000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 7981.xml