Psychopathological consequences of maltreatment among children and adolescents: A systematic review of the GxE literature. (November 2018)

• Record Type: Journal Article
• Authors: Maglione, Dario; Caputi, Marcella; Moretti, Benedetta; Scaini, Simona
• Is Part Of: Research in developmental disabilities. Volume 82(2018)
• Page Start: 53
• Page End: 66
• Publication Date: 2018-11
• Subjects: Gene-By-Environment interaction -- Maltreatment -- Children -- Adolescents -- Developmental psychopathology; Developmental disabilities -- Periodicals; Developmentally disabled -- Research -- United States -- Periodicals; Developmentally disabled children -- Education -- Research -- United States -- Periodicals; Developmental Disabilities -- Periodicals; Disabled -- Periodicals; Mental Retardation -- rehabilitation -- Periodicals; Personnes atteintes de troubles du développement -- Recherche -- États-Unis -- Périodiques; Enfants atteints de troubles du développement -- Éducation -- Recherche -- États-Unis -- Périodiques; Développement, Troubles du -- Recherche -- États-Unis -- Périodiques; 616.858800
• DOI: 10.1016/j.ridd.2018.06.005
• Languages: English
• ISSNs: 0891-4222

Abstract

Highlights: Child maltreatment is a significant risk factor for developmental psychopathology. Various genes interact with maltreatment in determining dysfunctional outcomes. Multiple genotypes interact with environment in case of maltreatment (GxGxE). A multi-genic approach and a better specification of maltreatment are warranted. Abstract: Background: In the last years, several studies focused on the role of Gene-Environment interactions (GxE) in influencing psychopathological outcomes among maltreated children and adolescents. These studies analysed the effect of different genetic variations. Aims: The aim of the present review is to provide an overview of studies investigating GxE effects among maltreated children and adolescents. Methods and Procedures: A systematic literature review was performed by using the following keywords: "Child maltreatment" and "GxE", "Child maltreatment" and "Psychopathology", "Gene-Environment interaction", "Gene-environment correlation", "GxE and psychopathology", "Childhood trauma" and "Psychiatric symptoms", "Early adverse life events", "Early life stress", "Antisocial behaviour", "Depression", "Internalizing symptoms", through the following electronic databases: PubMed, Scopus and PsycINFO, from 2006 to 2017, finding a total of 31 papers. Outcomes and Results: The present review confirm that maltreatment produces worse psychopathological outcomes (antisocial behaviour, depression, and other psychiatric traits) in subjects with a specific genetic vulnerability. Conclusions and Implications: Comprehending the pathways from child maltreatment to psychopathology in their full complexity will be essential to build efficacious preventive and therapeutic protocols.