Network characteristics in benign epilepsy with centro-temporal spikes patients indicating defective connectivity during spindle sleep: A partial directed coherence study of EEG signals. Issue 11 (November 2018)

• Record Type: Journal Article
• Authors: Varotto, Giulia; Franceschetti, Silvana; Caputo, Davide; Visani, Elisa; Canafoglia, Laura; Freri, Elena; Ragona, Francesca; Avanzini, Giuliano; Panzica, Ferruccio
• Is Part Of: Clinical neurophysiology. Volume 129:Issue 11(2018:Nov.)
• Page Start: 2372
• Page End: 2379
• Publication Date: 2018-11
• Subjects: Effective connectivity -- Benign childhood epilepsy -- Partial directed coherence; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2018.09.008
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: Partial directed coherence (PDC) showed increased out-flow in T4 and T3 of Right-BECTS and Left-BECTS patients only. During spindle-sleep, reduced in- and out-flow characterized most of the nodes in all BECTS patients. PDC indicates a condition of relatively isolated cortical areas possibly favouring epileptic activities. Abstract: Objective: To investigate the changes in EEG connectivity in children with the typical presentation of benign epilepsy with centro-temporal spikes (BECTS). Methods: We compared awake and spindle-sleep EEG recordings obtained by a standard electrode array in patients with lateralised (10 Right, 9 Left-BECTS) or bilateral spikes (10 MF-BECTS) and in 17 age-matched controls. We analysed EEG activity using partial directed coherence, an estimator of connectivity based on the multivariate autoregressive models and calculated in- and out-degrees, strength, clustering coefficient and betweenness centrality. Results: In comparison with the controls, the awake EEG recordings of the patients with lateralised BECTS showed a minimal increase in out-degrees on F4 and F3. The greater differences, found during sleep, included significant reductions in both in- and out-degrees and strength in all of the patient groups, but in T4 or T3 showing increased out-degrees and strength in Right and Left-BECTS. Betweenness centrality was significantly reduced on C3 and C4 in the patients with MF-BECTS. Conclusions: Our observations suggest that the main finding in BECTS patients is widely reduced local connectivity. Significance: The network changes in BECTS can be interpreted as a permissive condition occurring in a developmental window that predisposes to seizure generation during spindle-sleep.