Development of highly efficient nanocarrier-mediated delivery approaches for cancer therapy. Issue 1 (28th April 2016)

• Record Type: Journal Article
• Authors: Jeong, Keunsoo; Kang, Chi Soo; Kim, Youngsun; Lee, Yong-Deok; Kwon, Ick Chan; Kim, Sehoon
• Is Part Of: Cancer letters. Volume 374:Issue 1(2016)
• Page Start: 31
• Page End: 43
• Publication Date: 2016-04-28
• Subjects: Drug delivery -- Nanocarrier -- Cancer therapy -- Combination therapy -- Stimuli-activated therapy; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2016.01.050
• Languages: English
• ISSNs: 0304-3835

Abstract

Highlights: General aspects and advances of nanocarriers in a view of passive or active targeting modality in cancer therapy. Typical approaches of nanocarrier-mediated drug delivery through systemic or non-systemic administration. Recently devised functional nanocarriers with capability for co-integration of multi-drugs or for stimuli-activatable drug delivery. Abstract: Nanocarriers (NCs) are a group of nano-sized vehicles devised to deliver drugs to targeted malignant tissues or organs that provide remarkably improved targeting efficiency and therapeutic efficacy for cancer therapy. A variety of NCs have been developed to accommodate appropriate loading and release of drugs with a wide spectrum of chemical and physical characteristics. In addition, physicochemical modifications to the surface or interior of NCs allow for modulation of pharmacokinetic features reflecting clinical demands. However, cancer-related mortality is still high and drug-mediated cancer treatment remains a challenging research field despite the remarkable advances in targeting efficiency and therapeutic efficacy resulting from NCs. In this review, we focus on typical approaches and recent trends in NC-mediated drug delivery systems and their potential for targeted cancer therapy.