Abuse Potential of Biased Mu Opioid Receptor Agonists. (November 2018)

• Record Type: Journal Article
• Authors: Negus, S. Stevens; Freeman, Kevin B.
• Is Part Of: Trends in pharmacological sciences. Volume 39:Number 11(2018)
• Page Start: 916
• Page End: 919
• Publication Date: 2018-11
• Subjects: mu opioid receptor -- abuse potential -- bias -- reward -- reinforcement; Pharmacology -- Periodicals; Pharmacology -- trends -- Periodicals; Pharmacologie -- Périodiques; Pharmacology; Electronic journals; Periodicals; 615.1
• DOI: 10.1016/j.tips.2018.08.007
• Languages: English
• ISSNs: 0165-6147

Abstract

Abstract : G protein-biased mu opioid receptor (GPB-MOR) agonists constitute an emerging class of opioid analgesics. The first-in-class GPB-MOR agonist TRV130 (oliceridine) produces typical opioid-like abuse-related effects in rodents and humans. Although GPB-MOR agonists may be safer than conventional opioids on some endpoints, prevailing evidence suggests that they will retain opioid-like abuse potential.