A tumor-suppressive microRNA, miR-504, inhibits cell proliferation and promotes apoptosis by targeting FOXP1 in human glioma. Issue 1 (28th April 2016)

• Record Type: Journal Article
• Authors: Cui, Run; Guan, Yanlei; Sun, Chuanqi; Chen, Ling; Bao, Yijun; Li, Guangyu; Qiu, Bo; Meng, Xin; Pang, Chao; Wang, Yunjie
• Is Part Of: Cancer letters. Volume 374:Issue 1(2016)
• Page Start: 1
• Page End: 11
• Publication Date: 2016-04-28
• Subjects: Glioma -- microRNA -- miR-504 -- Forkhead box protein P1 -- Downregulation; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2016.01.051
• Languages: English
• ISSNs: 0304-3835

Abstract

Highlights: MiR-504 downregulation correlated with aggressive clinicopathological features and poor survival in glioma patients. MiR-504 suppresses glioma tumorigenicity both in vitro and in vivo . MiR-504 regulated glioma tumorigenesis by downregulating expression of its direct target, FOXP1. MiR-504 might function as an important tumor suppressor of glioma tumorigenesis. Abstract: MicroRNAs (miRNAs) have been proposed as useful prognostic cancer biomarkers and as potential molecular targets for treating various cancers. Previous findings have indicated that miR-504 is dysregulated and involved in tumorigenesis of several types of cancer. However, the biological role of miR-504 in glioma remains unclear. In this study, we showed that miR-504 expression was markedly decreased in both glioma tissues and cell lines and that miR-504 downregulation significantly correlated with aggressive clinicopathological features and poor prognosis for glioma patients. In addition, miR-504 overexpression inhibited cell proliferation, induced cell cycle arrest, and promoted apoptosis in glioma cell lines. Furthermore, we identified forkhead box protein P1 (FOXP1) as a direct target of miR-504 using microarray analysis and a luciferase assay. Moreover, we demonstrated that miR-504 regulated glioma tumorigenesis by downregulating FOXP1 expression. Our results suggest that miR-504 might function as an important suppressor of glioma tumorigenesis and could serve as a promising candidate for therapeutic applications in glioma treatment.