Auditory gamma oscillations predict global symptomatic outcome in the early stages of psychosis: A longitudinal investigation. Issue 11 (November 2018)

• Record Type: Journal Article
• Authors: Koshiyama, Daisuke; Kirihara, Kenji; Tada, Mariko; Nagai, Tatsuya; Fujioka, Mao; Ichikawa, Eriko; Ohta, Kazusa; Tani, Motoko; Tsuchiya, Maiko; Kanehara, Akiko; Morita, Kentaro; Sawada, Kingo; Matsuoka, Jun; Satomura, Yoshihiro; Koike, Shinsuke; Suga, Motomu; Araki, Tsuyoshi; Kasai, Kiyoto
• Is Part Of: Clinical neurophysiology. Volume 129:Issue 11(2018:Nov.)
• Page Start: 2268
• Page End: 2275
• Publication Date: 2018-11
• Subjects: Gamma-band auditory steady-state response (ASSR) -- Ultra-high risk -- Recent-onset schizophrenia -- Longitudinal study -- The global assessment of functioning (GAF) -- Symptomatic outcome; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2018.08.007
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: 40-Hz auditory steady-state response (ASSR) predicts the prognosis in early psychosis in this study. 40-Hz ASSR reduction correlates with global symptomatic outcome after 1–2 years. 40-Hz ASSR may be a useful biomarker of the long-term prognosis in early psychosis. Abstract: Objectives: The gamma-band auditory steady-state response (ASSR) is thought to reflect the function of parvalbumin-positive γ-aminobutyric acid (GABA)-ergic interneurons and may be a candidate biomarker in early psychosis. Although previous cross-sectional studies have shown that gamma-band ASSR is reduced in early psychosis, whether reduced gamma-band ASSR could be a predictor of the long-term prognosis remains unknown. Methods: In this longitudinal study, we investigated the association between gamma-band ASSR reduction and future global symptomatic or functional outcome in early psychosis. We measured 40-Hz ASSR in 34 patients with recent-onset schizophrenia (ROSZ), 28 ultra-high risk (UHR) individuals, and 30 healthy controls (HCs) at baseline. After 1–2 years, we evaluated the global assessment of functioning (GAF) in the ROSZ (N = 20) and UHR (N = 20) groups. Results: The 40-Hz ASSR was significantly reduced in the ROSZ and UHR groups. The attenuated 40-Hz ASSR was correlated with the future global symptomatic outcome in the ROSZ, but not in the UHR groups. Conclusions: A reduction in the gamma-band ASSR after the onset of psychosis may predict symptomatic outcomes in early psychosis. Significance: Gamma-band ASSR may be a potentially useful biomarker of the long-term prognosis in patients with recent-onset schizophrenia.