Effect of metformin on exercise capacity: A meta-analysis. (October 2018)

• Record Type: Journal Article
• Authors: Das, Saibal; Behera, Sapan Kumar; Srinivasan, Akila; Xavier, Alphienes Stanley; Selvarajan, Sandhiya; Kamalanathan, Sadishkumar; Sahoo, Jaya Prakash; Nair, N Sreekumaran
• Is Part Of: Diabetes research and clinical practice. Volume 144(2018)
• Page Start: 270
• Page End: 278
• Publication Date: 2018-10
• Subjects: Exercise -- Metformin -- Oxygen consumption -- Type 2 diabetes mellitus (T2DM); Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2018.08.022
• Languages: English
• ISSNs: 0168-8227

Abstract

Abstract: Aims: To evaluate the effect of metformin on various parameters of exercise capacity [oxygen consumption (VO2 ), peak oxygen consumption (VO2peak ), heart rate (HR), exercise test duration, respiratory exchange ratio (RER), rating of perceived exertion (RPE), lactate and ventilatory anaerobic threshold (VAT)]. Methods: Studies reporting change in VO2 or VO2peak after metformin administration were included. Subgroup analyses were performed as applicable. Mean difference with 95% CIs were pooled using random-effects model [RevMan (v5.3)]. Results: There were no changes in VO2 and VO2peak in the overall population [VO2 : n = 388, mean difference: −0.12 ml/kg/min, 95% CI: −0.74, 0.51, p = 0.71 (i 2 = 0%, p = 0.99); VO2peak : n = 345, mean difference: 0.41 ml/kg/min, 95% CI: −0.51, 1.33, p = 0.38 (i 2 = 0%, p = 0.89)], healthy volunteers and patients (type 2 diabetes mellitus, insulin resistance, impaired glucose tolerance/impaired fasting glucose and metabolic syndrome). For patients with insulin resistance, there was a decrease in VO2peak, but not VO2 . In the overall population, there was a significant decrease in HR and RER, a significant increase in RPE, and no changes in exercise test duration and VAT. In addition, there was an increased VAT in the healthy volunteers. Conclusions: In the overall population, metformin did not affect VO2, VO2peak, exercise test duration and VAT, although it significantly decreased HR, RER and increased RPE.