Mitochondrial DNA copy number of peripheral blood in bipolar disorder: The present study and a meta-analysis. (November 2018)

• Record Type: Journal Article
• Authors: Yamaki, Naruhisa; Otsuka, Ikuo; Numata, Shusuke; Yanagi, Masaya; Mouri, Kentaro; Okazaki, Satoshi; Boku, Shuken; Horai, Tadasu; Ohmori, Tetsuro; Shirakawa, Osamu; Sora, Ichiro; Hishimoto, Akitoyo
• Is Part Of: Psychiatry research. Volume 269(2018)
• Page Start: 115
• Page End: 117
• Publication Date: 2018-11
• Subjects: Mitochondria -- Bipolar disorder (BD) -- Meta-analysis; Psychiatry -- Periodicals; Psychiatry -- periodicals; Psychiatrie -- Périodiques; 616.89
• DOI: 10.1016/j.psychres.2018.08.014
• Languages: English
• ISSNs: 0165-1781

Abstract

Highlights: Bipolar disorder (BD) had low mitochondrial DNA copy number (mtDNAcn) than controls. Meta-analysis for all studies showed no association of mtDNAcn alteration with BD. Asian-specific meta-analysis showed lower mtDNAcn of BD than controls. Abstract: Numerous evidence indicated mitochondrial abnormalities in the pathophysiology of bipolar disorder (BD); however, it remains unclear whether aberrant mitochondrial DNA (mtDNA) copy number (cn) occur in BD due to the conflicting results in previous studies. Here, peripheral blood mtDNAcn in 69 BD patients and 54 controls were analysed via qPCR. BD patients had significantly lower mtDNAcn compared to controls (regardless of their BD type [BD I or II]). Meta-analysis for all previous BD-mtDNAcn studies combining our results with previously published studies failed to identify any significant association. Meanwhile, Asian-specific meta-analysis remarkably revealed lower mtDNAcn in BD patients.