Role of neutrophils in allergic asthma. (October 2018)

• Record Type: Journal Article
• Authors: Radermecker, Coraline; Louis, Renaud; Bureau, Fabrice; Marichal, Thomas
• Is Part Of: Current opinion in immunology. Volume 54(2018)
• Page Start: 28
• Page End: 34
• Publication Date: 2018-10
• Subjects: Immunology -- Periodicals; Allergy -- Periodicals; Immunology -- Abstracts -- Periodicals; Allergy -- Abstracts -- Periodicals; 616.079
• DOI: 10.1016/j.coi.2018.05.006
• Languages: English
• ISSNs: 0952-7915

Abstract

Abstract : The contribution of neutrophils to asthma pathogenesis has been mainly studied in the context of non-allergic neutrophilic asthma. However, neutrophils can also be rapidly recruited and are largely present in the airways of allergic eosinophilic asthmatic patients. Under these circumstances, they possess specific phenotypic features distinguishing them from resting blood neutrophils and are endowed with particular functions. The exact contribution of neutrophils to allergic asthma pathogenesis is still unclear, but growing experimental evidence supports the ability of neutrophils or neutrophil-derived products to influence the underlying allergic type 2 immune response and cardinal features of allergic asthma, thus shedding new light on neutrophil biology and functions in an allergic context.