Catalytic asymmetric transfer hydrogenation of ketones: recent advances. Issue 15 (31st August 2015)

• Record Type: Journal Article
• Authors: Foubelo, Francisco; Nájera, Carmen; Yus, Miguel
• Is Part Of: Tetrahedron, asymmetry. Volume 26:Issue 15/16(2015)
• Page Start: 769
• Page End: 790
• Publication Date: 2015-08-31
• Subjects: Alloc allyloxycarbonyl -- [bmim]+ N-butyl-N-methylimidazolium -- Bn benzyl -- Boc tert-butoxycarbonyl -- BRu [RuCl2(benzene)]2 -- Bz benzoyl -- cat catalyst -- Cbz benzyloxycarbonyl -- COD 1, 5-cyclooctadiene -- COE cyclooctene -- conv conversion -- Cp∗ pentamethylcyclopentadienyl -- CRu [RuCl2(p-cymene)]2 -- CTAB cetyltrimethylammonium bromide -- Cy cyclohexyl -- DMSO dimethyl sulfoxide -- dr diastereomeric ratio -- DTAB dodecyltrimethylammonium bromide -- DVB 1, 4-divinylbenzene -- ee enantiomeric excess -- equiv equivalent(s) -- Et ethyl -- HRu [RuCl2(Me6C6)]2 -- i-Bu isobutyl -- i-Pr isopropyl -- L ligand -- Me methyl -- MRu [RuCl2(mesitylene)]2 -- n-Pr n-propyl -- PEG polyethylene glycol -- Ph phenyl -- PS polystyrene -- SBA Santa Barbara University at California -- TBAI tetrabutylammonium iodide -- t-Bu tert-butyl -- Tf trifluoromethylsulfonyl -- THF tetrahydrofuran -- Ts 4-methylphenylsulfonyl -- TsDPEN N-(p-toluenesulfonyl)-1, 2-diphenylethylene diamine; Asymmetry (Chemistry) -- Periodicals; 547.005
• DOI: 10.1016/j.tetasy.2015.06.016
• Languages: English
• ISSNs: 0957-4166

Abstract

Graphical abstract: Abstract: In this review, we consider the main processes for the asymmetric transfer hydrogenation of ketones from 2008 up today. The most effective organometallic compounds (derived from Ru, Rh, Ir, Fe, Os, Ni, Co, and Re) and chiral ligands (derived from amino alcohols, diamines, sulfur- and phosphorus-containing compounds, as well as heterocyclic systems) will be shown paying special attention to functionalized substrates, tandem reactions, processes under non-conventional conditions, supported catalysts, dynamic kinetic resolutions, the use of water as a green solvent, theoretical and experimental studies on reaction mechanisms, enzymatic processes, and finally applications to the total synthesis of biologically active organic molecules.