Europium(III)-induced water-soluble nano-aggregates of hyaluronic acid and chitosan: structure and fluorescence. (25th June 2018)

• Record Type: Journal Article
• Authors: Guo, Junlan; Tang, Jianguo; Wang, Jing; Mao, Sui; Li, Haidong; Wang, Yao; Liu, Jin; Wang, Jing; Wang, Yanxin; Huang, Linjun; Kipper, Matt J.; Belfiore, Laurence A.
• Is Part Of: MRS communications. Volume 8:Number 3(2018)
• Page Start: 1224
• Page End: 1229
• Publication Date: 2018-06-25
• Subjects: Materials -- Periodicals; 620.11
• DOI: 10.1557/mrc.2018.107
• Languages: English
• ISSNs: 2159-6859

Abstract

Abstract: Abstract : This paper presents new water-soluble bio-polyelectrolyte-based nanoparticles, formed from lanthanide-induced polysaccharide aggregates (LIPAs). These new nano-aggregates are formed by coordinating a photoluminescent lanthanide–ligand complex to a single polyelectrolyte [i.e. polyanionic hyaluronic acid (HA)] or to two oppositely charged polyelectrolytes [i.e. HA and polycationic chitosan (CHI)]. We demonstrate that photoluminescent Eu 3+ –ligand complexes, which are dispersed homogeneously in aqueous solution by the association with water-soluble HA. The polysaccharide supermolecular assembly can be tuned to obtain nanoparticles of different sizes and surface charges. The preparation of stable and water-soluble lanthanide complexes via Eu 3+ –LIPAs opens opportunities for use of luminescent lanthanides in aqueous environments, for biosensing and bioimaging applications.