Manganese(ii) complexes with the non-steroidal anti-inflammatory drugs naproxen and mefenamic acid: synthesis, structure, antioxidant capacity, and interaction with albumins and DNA. (18th September 2018)

• Record Type: Journal Article
• Authors: Dimiza, Filitsa; Raptopoulou, Catherine P.; Psycharis, Vassilis; Papadopoulos, Athanasios N.; Psomas, George
• Is Part Of: New journal of chemistry. Volume 42:Number 20(2018)
• Page Start: 16666
• Page End: 16681
• Publication Date: 2018-09-18
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c8nj03226b
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : The structure, antioxidant activity and interaction with DNA and albumins of a series of manganese(ii ) complexes of mefenamic acid or naproxen are presented herein. Abstract : The interaction of the non-steroidal anti-inflammatory drugs naproxen or mefenamic acid with MnCl2 in the presence of the nitrogen-donor ligands 2, 2′-bipyridine, 1, 10-phenanthroline, 2, 2′-bipyridylamine or pyridine resulted in the formation of one dinuclear and four mononuclear Mn(ii ) complexes. The complexes were characterized by diverse physicochemical and spectroscopic techniques and single-crystal X-ray crystallography. The biological activity of the complexes was evaluated in regard to their ability to scavenge the free radicals of 1, 1-diphenyl-2-picrylhydrazyl, 2, 2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and hydroxyl and their binding affinity towards calf-thymus (CT) DNA and serum albumins. The complexes exhibit noteworthy scavenging activity towards ABTS and hydroxyl radicals; they can bind tightly to CT DNA via intercalation and can bind to bovine or human serum albumins tightly and reversibly.