Phosphorescent cyclometalated iridium(iii) complexes: synthesis, photophysics, DNA interaction, cellular internalization, and cytotoxic activity. (20th September 2018)

• Record Type: Journal Article
• Authors: Bhat, Satish S.; Revankar, Vidyanand K.; Pinjari, Rahul V.; Naveen, S.; Lokanath, N. K.; Kumbar, Vijay; Bhat, Kishore; Kokare, Dhoolesh G.
• Is Part Of: New journal of chemistry. Volume 42:Number 20(2018)
• Page Start: 16846
• Page End: 16854
• Publication Date: 2018-09-20
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c8nj03390k
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : Phosphorescent cyclometalated quinoline-appended iridium(iii ) complexes undergo rapid cellular internalization and accumulate throughout the cell. Abstract : Iridium(iii ) complexes containing quinoline-appended polypyridyl ligands [Ir(ppy)2 (qip)] + (1 ) and [Ir(bhq)2 (qip)] + (2 ) {ppy = 2-phenylpyridine, bhq = benzo[ h ]quinoline, Qip = 2(1 H )-quinolinone-3(1 H )-imidazo[4, 5 f ][1, 10]phenanthrolin-2-yl} have been synthesized and characterized. The structure of complex2 has been determined by single crystal X-ray crystallography. The experimental photophysical properties of the complexes have been compared with the theoretically obtained results by density functional theory (DFT) and time-dependent density functional theory (TD-DFT) studies. The HOMO of the complexes is mainly localized on the iridium atom while the LUMO is mainly localized on the proximal position of the N–N donor polypyridyl ligand and the LUMO+1 is localized on the distal portion of the N–N donor polypyridyl ligand. The binding of complexes to double-stranded calf thymus DNA (CT-DNA) has been investigated by absorption and emission spectroscopic techniques. The electrophoretic mobility shift assay of plasmid DNA in the presence of complexes shows DNA aggregation at micro-molar concentration. These complexes have low toxicity and their strong intracellular luminescence highlights their potential as theragnostic agents.