Integrated plug flow synthesis and crystallisation of pyrazinamide. Issue 5 (25th July 2018)

• Record Type: Journal Article
• Authors: Scott, C. Daniel; Labes, Ricardo; Depardieu, Martin; Battilocchio, Claudio; Davidson, Matthew G.; Ley, Steven V.; Wilson, Chick C.; Robertson, Karen
• Is Part Of: Reaction chemistry & engineering. Volume 3:Issue 5(2018)
• Page Start: 631
• Page End: 634
• Publication Date: 2018-07-25
• Subjects: Reaction mechanisms (Chemistry) -- Periodicals; Chemical engineering -- Periodicals; Chemical engineering; Reaction mechanisms (Chemistry); Periodicals; 547.705
• DOI: 10.1039/c8re00087e
• Languages: English
• ISSNs: 2058-9883

Abstract

Abstract : Pure pyrazinamide has been produced in a coupled flow synthesis and crystallisation in high yield, pure polymorphic form (γ) and narrow particle size distribution. Abstract : We report the integration of flow chemistry with plug flow crystallisation. Catalytic flow hydration of pyrazinecarbonitrile to pyrazinamide was performed in a packed bed column of MnO2 . The effluent of this flow reactor was directly linked to a tri-segmented tubular crystalliser (KRAIC), providing a seamless transition from flow synthesis to crystallisation, with control over solid form and particle characteristics.