Molecular and clinical aspects of embryotoxicity induced by acetylcholinesterase inhibitors. (1st November 2018)

• Record Type: Journal Article
• Authors: Tsiaoussis, J.; Hatzidaki, E.; Docea, A.O.; Nikolouzakis, T.K.; Petrakis, D.; Burykina, T.; Mamoulakis, C.; Makrigiannakis, A.; Tsatsakis, A.
• Is Part Of: Toxicology. Volume 409(2018)
• Page Start: 137
• Page End: 143
• Publication Date: 2018-11-01
• Subjects: ACh acetylcholine -- AChE acetylcholinesterase -- AChEIs acetylcholinesterase inhibitors -- ASD Autism Spectrum Disorder -- BuChE pseudocholinesterase -- EDs endocrine disruptors -- PIP2 phosphatidylinositol (3, 4)-bisphosphate -- PIP3 phosphatidylinositol (3, 4, 5)-trisphosphate -- PI3K phosphatidylinositol 3-kinase -- PDK1 phosphoinositide-dependent kinase 1 -- Akt protein kinase B -- mTOR mammalian target of rapamycin -- HIF1a hypoxia-inducible factor 1-alpha -- VEGF vascular endothelial growth factor -- IL-1β interleukin1 beta -- IL-1R1 interleukin 1 receptor type 1 -- iNOS inducible nitric oxide synthase; Cholinesterase inhibitors -- Endocrine disruptors -- Fetus -- Organophosphates -- Parasympathomimetics -- Toxicity; Toxicology -- Periodicals; Chemicals -- Physiological effect -- Periodicals; 615.9005
• DOI: 10.1016/j.tox.2018.07.018
• Languages: English
• ISSNs: 0300-483X

Abstract

Abstract: Acetylcholinesterase inhibitors are widely used for a variety of medical, agricultural and public health purposes. Consequently, exposure is highly possible during lifetime. However, their systematic use raises concerns for the potential impact on the fetus and newborn since these substances may affect angiogenesis, the neonatal and maternal intensive care, neuroimmune function and response, mammary growth/lactation via cholinergic/non-cholinergic central and peripheral neuroendocrine pathways. New methodologies, neuroscientific technologies and research studies are needed to harness existing knowledge along with the proper management, availability for new acetylcholinesterase inhibitors, with stable pharmacodynamics and clinical outcomes.