The associated volumes of sub-cortical structures and cognitive domain in patients of Mild Cognitive Impairment. (October 2018)

• Record Type: Journal Article
• Authors: Qian, Lai; Liu, Renyuan; Qin, Ruomeng; Zhao, Hui; Xu, Yun
• Is Part Of: Journal of clinical neuroscience. Volume 56(2018)
• Page Start: 56
• Page End: 62
• Publication Date: 2018-10
• Subjects: 3D-TFE Three-Dimensional Turbo Fast Echo -- AD Alzheimer's disease -- ADL Activities of Daily Living -- AFT Animal Fluency Test -- AVLT Auditory Verbal Learning Test -- AVLT-R Auditory Verbal Learning Test Recall -- BNT Boston Naming Test -- CA Cornu Ammonis -- CDR Clinical Dementia Rating -- CDT Clock Drawing Test -- DST Digit Span Test -- DSM-V Diagnostic and Statistical Manual of Mental Disorders-V -- FOV Field Of View -- HAMA Hamilton Anxiety Rating Scale -- HAMD Hamilton Depression Rating Scale -- IADL Instrumental Activities of Daily Living -- LMT Logical Memory Test -- LMT-R Logical Memory Test Recall -- MCI Mild Cognitive Impairment -- MMSE Mini-Mental State Examination -- MOCA Montreal Cognitive Assessment -- NPI Neuropsychiatric Inventory -- NSA Number of Signal Averaged -- pMCI progress Mild Cognitive Impairment -- SFT Speech Fluency Test -- sMCI stable Mild Cognitive Impairment -- TE Echo Time -- TMT Trail Making Test -- TR Repetition Time -- T2WI T2 Weighted Imaging -- VCT Visual Coping Test -- VCT-R Visual Coping Test Recall -- VST Victoria Stroop Test -- WMH White Matter Hyperintensity; Sub-cortical structures -- Cognitive domain -- Mild Cognitive Impairment; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2018.07.010
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: Progress MCI patients had lower scores in memory, language, executive and visual spatial. The volumes of sub-cortical structures in stable MCI and progress MCI patients were heterogeneous. Left hippocampus was predicted region for memory. Left thalamus was predicted region for language, executive and visual spatial. Abstract: This study aimed to explore the relationship between sub-cortical structures alterations and the cognitive domains in Mild Cognitive Impairment (MCI) patients, expected to find identifying sub-cortical structure markers of MCI progression to dementia. A total of 67 MCI patients (8 subjects refused to follow up) were recruited, who were divided into 21 stable MCI (sMCI) and 38 progress MCI (pMCI), according to cognitive assays. FreeSurfer software was used to perform volumetric measurements of the sub-cortical structures from 3.0 T magnetic resonance scans. Data revealed that pMCI subjects had lower scores in memory, language, executive and visual spatial compared with sMCI subjects. Compared with the sMCI group, the volume of the left thalamus, bilateral hippocampus, corpus callosum posterior and corpus callosum central was smaller in pMCI subjects. Partial correlation and general linear regression analysis showed that the left hippocampus was predicted region for memory, left thalamus was predicted region for language, executive and visual spatial. These current results suggest that the volumes of sub-cortical structures in stable MCI and progress MCI patients were heterogeneous. Among these regions, the left hippocampus was predicted region for memory, left thalamus was predicted region for language, executive and visual spatial, suggesting that these structures might be important for detecting the subtle effects of MCI patients' cognitive domain or to assess the effectiveness of therapeutic intervention for MCI.