Addiction and dopamine: sex differences and insights from studies of smoking. (October 2018)

• Record Type: Journal Article
• Authors: Petersen, Nicole; London, Edythe D
• Is Part Of: Current opinion in behavioral sciences. Volume 23(2018)
• Page Start: 150
• Page End: 159
• Publication Date: 2018-10
• Subjects: Psychology -- Periodicals; 150.5
• DOI: 10.1016/j.cobeha.2018.07.002
• Languages: English
• ISSNs: 2352-1546

Abstract

Highlights: Sex differences in substance use disorders are related to dopaminergic dysfunction. Genes underlying dopamine function produce different behaviors in men and women. Hormone interactions with the dopamine system are a priority for future investigations. Smoking research provides insight into sex differences in therapeutic targets. Abstract : Mesolimbic dopaminergic function influences addiction through effects on reinforcement learning, decision-making, and impulsivity. This review covers sex differences in dopaminergic neurochemistry, their hormonal and genetic determinants, and how differences in dopaminergic tone interact with sex and/or ovarian hormone status to affect cognitive functions. Findings from research on cigarette smoking reveal sex differences in striatal and midbrain dopamine D2-type receptor availability and striatal dopamine release that suggest mechanisms of nicotine dependence, and stronger subjective responses to nicotine and efficacy of nicotine replacement therapies in male smokers than in their female counterparts. Opportunities exist to extend such efforts in studies of how sex and hormone status influence other addictions.