Vitamin D protection from rat diabetic nephropathy is partly mediated through Klotho expression and renin–angiotensin inhibition. (20th October 2018)

• Record Type: Journal Article
• Authors: Eltablawy, Nashwa; Ashour, Hend; Rashed, Laila Ahmed; Hamza, Wael Mostafa
• Is Part Of: Archives of physiology and biochemistry. Volume 124:Number 5(2018)
• Page Start: 461
• Page End: 467
• Publication Date: 2018-10-20
• Subjects: Vitamin D -- Klotho -- losartan -- diabetic nephropathy; Physiology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Biochemistry; Physiology; 571
• DOI: 10.1080/13813455.2018.1423624
• Languages: English
• ISSNs: 1381-3455

Abstract

Abstract: Objective: We hypothesised that vitamin D has a beneficial renal protective effect from diabetic nephropathy (DN). Methods: Four rat groups were included: normal control (control), type 2 diabetes for eight weeks (DM), treated group with angiotensin receptor blocker losartan (DM + L), and vitamin D-treated group started from the onset of diabetes (DM + Vit D). Results: In the both treated groups, we found a significant ( p < .05) reduction in the renal pro-inflammatory and profibrotic markers induced by diabetes. Vitamin D caused more reduction in monocyte chemoattractant protein-1 (MCP-1), transforming growth factor (TGFβ-1), and renin–angiotensin levels that gave better kidney function compared to the DM + L group. Conclusion: Vitamin D may have a valuable role in the renal protective effect from DN, this may occur via expression of its VDR, Klotho and blocking renin–angiotensin activation, so vitamin D should be considered as a target in renal prophylactic measures against DN.