Modeling Diversity: Do Homogeneous Laboratory Strains Limit Discovery?. Issue 11 (November 2018)

• Record Type: Journal Article
• Authors: Smith, Clare M.; Sassetti, Christopher M.
• Is Part Of: Trends in microbiology. Volume 26:Issue 11(2018)
• Page Start: 892
• Page End: 895
• Publication Date: 2018-11
• Subjects: infectious diseases -- tuberculosis -- host genetics -- mouse models -- genetic diversity -- Collaborative Cross; Microbiology -- Periodicals; Infection -- Periodicals; Virulence (Microbiology) -- Periodicals; Infection -- Periodicals; Microbiology -- Periodicals; Virulence -- Periodicals; Microbiologie -- Périodiques; Infection -- Périodiques; Virulence (Microbiologie) -- Périodiques; Infection; Microbiology; Virulence (Microbiology); 579
• DOI: 10.1016/j.tim.2018.08.002
• Languages: English
• ISSNs: 0966-842X

Abstract

Abstract : The outcome of chronic infections is highly variable. The heterogeneous disease outcomes in natural populations differ from genetically homogeneous infection models. Here, we use tuberculosis as a 'case study' to contrast the genetic landscape in natural populations with standard infection models, discussing new strategies to bridge this gap.