Primary orbital melanoma: a case series and literature review. (3rd September 2018)

• Record Type: Journal Article
• Authors: Figueira, Edwin; Rajak, Saul; McKelvie, Penny; Kalantzis, George; Ismail, Azzam; Gonzales, Michael; James, Craig; McNab, Alan; Selva, Dinesh
• Is Part Of: Orbit. Volume 37:Number 5(2018)
• Page Start: 352
• Page End: 357
• Publication Date: 2018-09-03
• Subjects: Adjuvant treatment -- blue cellular naevus -- congenital ocular melanocytosis -- exenteration -- orbit -- primary orbital melanoma; Eye-sockets -- Surgery -- Periodicals; Eye-sockets -- Diseases -- Periodicals; Orbit -- surgery -- Periodicals; Orbital Diseases -- Periodicals; 617.7
• DOI: 10.1080/01676830.2017.1423354
• Languages: English
• ISSNs: 0167-6830

Abstract

ABSTRACT: Primary orbital melanoma (POM) is a very rare condition. We report further four cases and review all previously reported cases. We present a multicentre retrospective review of patients with POM. Clinical, radiological, surgical, histological, and follow-up data is presented. Four patients with POM were identified between 2000 and 2013. All presented with proptosis and diplopia without reduced vision. Two had known pre-existing blue cell naevi. All were stage T1N0M0. All underwent exenteration with adjuvant radiotherapy. All are disease free at follow-up durations of 24–151 months. The present three cases and review of all cases in the literature suggest a higher likelihood of disease-free survival from primary exenteration (7/8 disease-free survival, 1/8 death from metastatic disease) than wide local excision (7/16 disease-free survival, 9 recurrence or metastasis of whom 4 died). Adjuvant radiotherapy may additionally improve outcomes.