Role of C1 neurons in anti-inflammatory reflex: Mediation between afferents and efferents. (November 2018)

• Record Type: Journal Article
• Authors: Abe, Chikara; Inoue, Tsuyoshi
• Is Part Of: Neuroscience research. Volume 136(2018)
• Page Start: 6
• Page End: 12
• Publication Date: 2018-11
• Subjects: Sympathetic nerve -- Parasympathetic nerve -- Vagus -- Inflammation -- Neuroimmune system; Neurosciences -- Research -- Periodicals; Neurosciences -- Research -- Japan -- Periodicals; Neurology -- Periodicals; Neurosciences -- Periodicals; Neurosciences -- Recherche -- Périodiques; Neurosciences -- Recherche -- Japon -- Périodiques; Neurosciences -- Research; Japan; Periodicals; 612.8
• DOI: 10.1016/j.neures.2018.05.001
• Languages: English
• ISSNs: 0168-0102

Abstract

Highlights: C1 neurons are involved in the anti-inflammatory response. Sympathoexcitation is required for anti-inflammatory response via C1 neurons. C1 neurons are involved in the cholinergic anti-inflammatory pathway. Abstract: Neuroimmune communication, the connection between the autonomic regulatory pathway and immune cells, has been implicated in the regulation of immune function and inflammation. The role of afferents (vagal afferent and somatic sensory nerves) and efferents (autonomic nervous and hypothalamic-pituitary-adrenal systems) in the inflammatory reflex has been well studied; however, the central pathway remains unknown. C1 neurons include both catecholaminergic and glutamatergic neurons, which are located in the rostral ventrolateral medulla. C1 neurons project to the spinal cord, dorsal motor nucleus of the vagus, and hypothalamus to regulate the sympathetic, parasympathetic, and hypothalamic-pituitary-adrenal systems, respectively. Because C1 neurons respond to stressors, including inflammation, hypotension, hypoxia, and hypoglycemia, it is believed that the autonomic regulatory pathway, via C1 neurons, contributes to the maintenance of physiological homeostasis. Recently, selective neural manipulation has revealed that C1 neurons participate in restraint stress-induced anti-inflammation, and protection against acute kidney injury has been attributed to stress-induced sympathoexcitation through C1 neurons. We focus here on the role of C1 neurons, which act as mediators between afferents and efferents, in the anti-inflammatory pathway.