Caloinophyllin A, a new chromanone derivative from Calophyllum inophyllum roots. Issue 21 (2nd November 2018)

• Record Type: Journal Article
• Authors: Ponguschariyagul, Sasa; Sichaem, Jirapast; Khumkratok, Suttira; Siripong, Pongpun; Lugsanangarm, Kiattisak; Tip-pyang, Santi
• Is Part Of: Natural product research. Volume 32:Issue 21(2018)
• Page Start: 2535
• Page End: 2541
• Publication Date: 2018-11-02
• Subjects: Calophyllum inophyllum -- Guttiferae -- caloinophyllin A -- chromanone derivative -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1425845
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new chromanone derivative, namely caloinophyllin A (1 ), along with eight known compounds (2 –9 ), nobiletin (2 ), pentamethylquercetin (3 ), 3, 5, 7, 4′-tetramethoxyflavone (4 ), 5, 7, 4′-trimethoxyflavone (5 ), 1, 5-dihydroxyxanthone (6 ), 1, 8-dimethoxy-2-hydroxyxanthone (7 ), 1, 6-dihydroxy-7-methoxyxanthone (8 ) and 4-methoxycaffeic acid (9 ) were isolated from the roots of Calophyllum inophyllum . The structures of all the isolated compounds (1 –9 ) were fully characterised using spectroscopic data, as well as comparison with the previous literature data. In addition, the quantum chemical calculation has been used to confirm the conformation of1 . Moreover, all isolated compounds were assessed for their in vitro cytotoxicity against five human cancer cell lines. Abstract :