Analysis and engineering of substrate shuttling by the acyl carrier protein (ACP) in fatty acid synthases (FASs). Issue 82 (28th September 2018) - Rossini, Emanuele
Abstract : Perturbations of domain–domain interactions impact the function of type I fatty acid synthases. Abstract : Perturbations of domain–domain interactions impact the function of type I fatty acid synthases. We identify interface point mutations that modulate fatty acid chain lengths, and explain their effect in changes of domain–domain binding energetics. Engineering of similar interfaces in related megasynthases may be exploited for custom synthesis of natural products.