In vitro and in vivo studies of a chlorin-based carbon nanocarrier with photodynamic therapy features. Issue 10 (16th August 2018)

• Record Type: Journal Article
• Authors: Zhou, Zhan; Zheng, Yuhui; Zhang, Cheng Cheng; Gao, Jinwei; Tang, Yiping; Wang, Qianming
• Is Part Of: Photochemical & photobiological sciences. Volume 17:Issue 10(2018)
• Page Start: 1329
• Page End: 1336
• Publication Date: 2018-08-16
• Subjects: Photochemistry -- Periodicals; Photobiology -- Periodicals; 541.35
• DOI: 10.1039/c8pp00287h
• Languages: English
• ISSNs: 1474-905X

Abstract

Abstract : Carbonaceous materials have long been developed to utilize "nano-spaces" and numerous guest species could be encapsulated. Abstract : Carbonaceous materials have long been developed to utilize "nano-spaces" and numerous guest species could be encapsulated. A remarkable fluorescence difference has been observed after newly designed pyropheophorbide-a-appended carbon nanohorns were incorporated in a cellular medium and confocal microscopy was employed for the determination of the intracellular localization. Our study supported the role of carbon nanohorns as carriers of photodynamic therapy (PDT) agents and their heating behavior was discussed. We have developed a theranostic platform based on photosensitizer-conjugated carbon nanostructures and this system has been applied in an animal model. In addition, a negligible toxicity of CNH-Pyro was found in body weight experiments and histopathological examination of the major organs.