Glyoxylamide-based self-assembly hydrogels for sustained ciprofloxacin delivery. Issue 38 (10th September 2018)

• Record Type: Journal Article
• Authors: Aldilla, Vina R.; Martin, Adam D.; Nizalapur, Shashidhar; Marjo, Christopher E.; Rich, Anne M.; Ho, Kitty K. K.; Ittner, Lars M.; Black, David StC.; Thordarson, Pall; Kumar, Naresh
• Is Part Of: Journal of materials chemistry. Volume 6:Issue 38(2018)
• Page Start: 6089
• Page End: 6098
• Publication Date: 2018-09-10
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c8tb01290c
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Glyoxylamide-based hydrogels have high ciprofloxacin (CIP) loading capacity and demonstrate a sustained release profile of over 15 days. Abstract : In this study, we report the synthesis of glyoxylamide peptide-mimics as self-assembled gels with well-defined molecular structures for topical delivery of ciprofloxacin (CIP). The glyoxylamide peptide mimics successfully formed hydrogels with critical gel concentrations of 0.02–0.08% (w/v). The mechanical strength, secondary structure, and fiber morphology of these hydrogels can be modulated by varying the N -substituent of the ring-opened isatins. The synthesised hydrogel exhibited a high loading capacity of CIP (40% (w/w)) and a sustained release profile. The CIP-loaded hydrogels were able to release CIP for more than 15 days and the released solution was shown to retain activity against Gram-positive and Gram-negative bacteria. In addition, the hydrogels formed showed low toxicity against Cos7 cells.